No. 2: The injury bug
Injuries have plagued Louisville since the season began in September, as several players have been questionable week to week, or even some players have been knocked out for the season.
Star linebacker Stanquan Clark was knocked out for the season for Louisville this season, where Clark was looking to be one of the more experienced and valued players on the defense in 2025. The running back room has seemingly been in shambles every week. As Isaac Brown, Duke Watson, and Keyjuan Brown have all been dealing with nagging injuries weekly.
If Louisville wants to play the best football it can, then it needs to stay healthy, especially on the offense, where it seems as if most of Louisville's star players on that side of the field are going down like flies, from running backs to wide receivers.
None is more important than the offensive line, where if one man goes down on that unit, the floodgates might open up more than they already have, which leads us to the #1 biggest threat to Louisville in 2025.