Final score prediction
From the previous two predictions, and with the over-under at 62.5, the fans should expect a high-scoring affair this weekend from the Cardinals and Cavaliers. Both offenses have shown the ability to light up the scoreboard, and this game will be no different.
Virginia has been especially dominant offensively in the first half, and in the past two showdowns between these two teams, UVA has led in the fourth quarter. While Louisville has started games a little slowly, the Cardinals have come out on top in the last three matchups against the Cavaliers, and last week showed they can make some noise in the second half.
This game will be a significant test for Louisville, revealing how it compares to the top teams in the ACC. The Cardinals will come out on top in an absolute nail-biter and will earn their biggest win of the season.
Prediction: Louisville 41 Virginia 37
Louisville and Virginia will kick off next Saturday, October 4, from L&N Stadium at 3:30 p.m. local time. For all the latest on Louisville football's 2025 season, stay tuned.