2. Louisville beats Clemson on Nov. 14
Louisville shocks the nation yet again and beats the Clemson Tigers for the second straight season. Dabo Swinney and his Tigers are going to come to L&N Stadium hungry, but this dominant rushing attack and explosive wide receiver room will be too much for the Tigers and hand them a loss yet again.
The Cardinals' Friday night showdown with Clemson is going to make or break their ACC Title dreams, possibly, and Brohm will get this team ready and have them make history yet again. If the Tigers win Week 1 against LSU, they have a good chance of coming into L&N Stadium undefeated and a top-five team in the nation, while Louisville might have a loss or two and a lot more to play for.
This game might be closer than it was last season, but the Cardinals earn the program's second win over the Tigers and will keep their ACC dreams alive.
Related: Floor, ceiling, and prediction for Louisville in 2025: Can the Cardinals win the ACC?