Louisville football is coming off a wild comeback win over Pitt and is now 4-0 going into their biggest game of the 2025 season. The Virginia Cavaliers are ranked No. 24 in the nation after their win over Florida State and are 4-1 on the season, with their only loss coming to North Carolina State.
Louisville ACC Title odds have been going up and down all season long, but thanks to the Cavaliers, they jumped Florida State, and now sit with the third-best odds to win the ACC, and they have a clear path to make history. That path starts with their crucial matchup this weekend, and they must win if they want a shot at playing in Charlotte.
Louisville has clear path to first-ever ACC Title
The Cardinals' four wins might not have been the prettiest, but at the end of the day, Louisville is 4-0 and is still in the ACC race. The Miami Hurricanes are the dominant favorite with odds of -115 to win the conference, and behind them, Georgia Tech sits with odds of +460, according to FanDuel.
After those two teams, Louisville fans saw the Cardinals' ACC odds increase following their win this weekend, as they surpassed Florida State and now have +960 odds to win the ACC, while Florida State has +1100 odds to win the conference after their loss to Virginia. The Cavaliers round out the top five with +1300 odds to win the ACC, making this weekend's game have massive implications on the ACC race.
A win for Louisville and the Cardinals sit 5-0 for just the second time in the last 12 years, and pick up a massive win over a ranked team. If Louisville were to lose this weekend, it would be a crushing blow to the Cardinals' ACC Title odds as they still have Miami and SMU on the road, and Clemson at home.
This matchup against Virginia should set the tone for the Cardinals' 2025 season and will either solidify them as an ACC contender or reveal that they might have a challenging back half of the 2025 season.
Related: 5 crucial games that will make or break the Louisville Cardinals' 2025 ACC Title push
Louisville and Virginia will kick off next Saturday, October 4, from L&N Stadium at 3:30 p.m. local time.