Week 12: vs Kentucky (Nov. 29th)
After falling to SMU, Louisville will look to send the College Football Playoff Committee a statement with a win over the Kentucky Wildcats. By the time this matchup happens, the Wildcats will be out of position for a bowl game, most likely, as the Cardinals are fighting for a spot in the ACC Championship game and the College Football Playoffs.
Louisville will dominate Kentucky just like last season and end the 2025 season with an absolute bang. The Cardinals' offense is even more explosive this year than last, making this game a blowout win in favor of Brohm and the Louisville Cardinals. The Governor's Cup will stay with Louisville, and the Cardinals fans will have a 10-win season for the second time in three seasons under Brohm.
Prediction: Louisville 38 Kentucky 20