Week 4: at Pittsburgh (Sep. 27th)
ESPN gives Louisville a slight edge over Pitt as of right now, but the Cardinals fans know how tricky this game can be. Louisville fans will never forget back in 2023 when the Cardinals dropped a 38-21 loss to Pitt after beating Notre Dame.
The Cardinals will head to Pitt undefeated again and hope for a different result, which they will likely achieve. The Panthers showed in their loss against West Virginia that they have a hard time stopping the run, as Tye Edwards ran for 141 yards and three touchdowns.
Isaac Brown and Miller Moss will lead the way and secure a massive ACC victory and skyrocket their ACC Title odds heading into Week 6.
Prediction: Louisville 31 Pitt 24
Related: Louisville football's season-defining game is much earlier than fans anticipated