Week 6: at Miami (October 17th)
The matchup Louisville fans are counting down for. The Cardinals host a 4-12 record against the Hurricanes, but their most recent win came two years ago at Hard Rock Stadium when Jeff Brohm led the Cardinals to a 38-31 victory.
This is going to be a rank vs rank matchup, and Miami looks the part as of right now. The Hurricanes have defeated two ranked teams and Florida and are proving they are not just the ACC frontrunner but a National Title contender.
Louisville will drop its first game of the 2025 season, but will sit 5-1 and still have a clear path to Charlotte to try and get redemption on the Hurricanes in the game that truly matters most.
Prediction: Miami 30 Louisville 24
Related: Louisville has prime chance to shake up College Football Playoff with one key game