Week 7: vs Boston College (Oct. 25th)
Entering the 2025 season, Boston College was thought of as one of those sleeper ACC teams that could play spoiler. Well, through three weeks of football, Louisville fans are not worried one bit about the Eagles, and if the Cardinals lose to Miami (which they will in this prediction), they will come out hungrier than ever and take all their anger out on Boston College.
Louisville is at home in this matchup and will dominate the Eagles just like they did two years ago at home when they won 56-28. Boston College is 1-2 as of today, with their losses coming to Michigan State and Stanford. Louisville's offense should steamroll the Eagles' weak defense and get the Cardinals back in the win column.
Prediction: Louisville 42 Boston College 24
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