Week 11: at SMU (Nov. 22nd)
SMU has had a slow start to the 2025 season as they are 2-2 after falling to TCU yesterday and Baylor in Week 2. The Mustangs defeated Louisville last year 31-24, and now, with SMU 2-2, they have a chance to play spoiler.
Louisville might have a chance to punch its ticket to the ACC Championship game with this matchup, but with SMU's most challenging games at home this season, the Mustangs' season is not over just yet. Kevin Jennings was unstoppable last year as he threw for 281 yards and rushed for 113. The Cardinals fall to the Mustangs and will drop to 9-2. Louisville's ACC Championship Title dreams could still be alive with a 6-2 ACC record, but Louisville fans must watch out for Florida State, Georgia Tech, SMU, and Miami moving forward.
Prediction: SMU 31 Louisville 27