Louisville football 2025 game-by-game predictions

With spring practice under way, and Louisville football officially knows who they play this season, and when, let's take a deep dive and predict each game for this upcoming 2025 season.
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With spring practice underway and Louisville football officially knowing who they play this season and when, let's take a deep dive and predict each game for this upcoming 2025 season.

Louisville football went 9-4 in 2024 with a 5-3 ACC record. The Cardinals have some new faces on this 2025 roster, including a new starting quarterback, and a whole new secondary. Former USC quarterback Miller Moss transferred to Jeff Brohm and the Cardinals this offseason, as the unanimous 4-star prospect will look to take over Tyler Shough, who declared for the NFL Draft.

So, how will Louisville football fair in the ACC with the giants like Clemson and Miami, and newcomer of SMU? Who will step up for Louisville?

Here are my predictions for each of Louisville football's games in the 2025 season.