Can the Cardinals do it? Can the Cardinals get it done and secure their second-ever win over the Clemson Tigers? This game will mark a three-game gauntlet of a stretch for Louisville football, and this game is vital for their ACC dreams.
It will come down to Miller Moss. The transfer quarterback has to be able to throw with Tigers quarterback Cade Klubnik and make smart decisions. This game will be close. The Cardinals blew the Tigers out last year, despite the final score of it only being 33-21.
Louisville is 1-8 all-time vs Clemson, and unfortunately, this Tigers offense will be just too much for the Tigers' weakness on the defensive side. Brown will do all he can like last year and try to rush for 150-plus again, but at the end of the day, this Tigers team is even better than last year, and Dabo Swinney will have them ready for this top-15 showdown in Louisville.
Cardinals will fall to the Tigers, and will fall to 8-2 on the year.