No. 2: Clemson Tigers (November 14th)
Going into this season, thinking about Clemson coming to Louisville on a Friday night in November sounds like the biggest game of the season, with no questions asked. Then, Clemson started the season with a 1-3 record. However, if the tigers can turn things around and have a decent record coming into the game, then who's to say it won't be a massive game for the Cardinals?
Clemson will likely play up for this game against the Cardinals after they got embarrassed at home last year against Louisville. Expect this game to be exceptionally close and a somewhat gritty matchup between two teams vying for a spot in the ACC championship game. Clemson's chances of making the championship are lower than usual, but if they start playing quality football and Georgia Tech/Miami slip up, then it is certainly possible.
Clemson wants a win against Louisville, and the Cardinals will be fighting to get as many wins as possible in late November. Expect this to be the biggest game of November, and a very big must-win game for Louisville.