Louisville basketball’s huge non-conference stretch is about to start, as the Cardinals are 2-0 and face a gauntlet. UofL is set to face Memphis on the road this Sunday, then face Texas Tech in the Player’s Era Tournament; after the tournament, they will face Texas, Michigan, and Kentucky.
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The Cardinals currently round out the top 10, as UofL ranks No. 10 after a 14-point win over Chattanooga and a 48-point win over Morehead State. Lousiville entered the year with lofty expectations, as the Cardinals have +2500 odds to win their first National Title since 2013.
So, with Louisville’s huge stretch of games now here, let’s break down the ACC odds and reveal the Cardinals' biggest threats.
Louisville has the third highest odds to win the ACC in 2026
The Cardinals entered the year with the third-highest odds to win the ACC Title, and as we approach the end of Week 2, the odds haven’t changed much. Right now, Louisville has the third-highest odds to win its first ACC Title, as it's still behind Duke and Virginia.
Despite losing their first game of the season to Michigan State, 79-73, Duke still has the best odds to win the ACC crown at -120, according to FanDuel. Following Duke are the Virginia Cavaliers, who are just ahead of Louisville, with +380 odds to win the ACC crown.
Rounding out the top three is the Louisville Cardinals at +480. However, the drop-off after the Cardinals is huge. The Blue Devils, Cavaliers, and Cardinals appear to be the heavy favorites for the ACC crown, as all three rank inside the top 10, but even though Miami ranks No. 17, FanDuel doesn’t see them as major threats just yet.
Miami currently has +1000 odds to win the ACC Title, and then another major gap follows, as Virginia Tech rounds out the top five at +2700 and UNC is at +3500, according to FanDuel.
The Cardinals will have a long time before they face Duke or Virginia, as they face both in their final five games of the season, with Louisville traveling to UVA on Feb. 15 and then the Cardinals hosting the NCAA Tournament national Title favorites, the Duke Blue Devils, on Feb. 24.
There is still so much basketball to be played, but the Cardinals' biggest threats are made clear by the Vegas oddsmakers. February will be a thrilling time for Louisville fans, and hopefully the Cardinals will have a handful of ranked wins by the time they face these other two ACC powerhouses.
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