Louisville football is coming off its first bye of the 2025 season as it will return to its home field this Saturday against Bowling Green for its third game of the season so far. The Cardinals are just outside of the AP top 25 with their 2-0 record, and will have a big chance to extend their win total to three against the Falcons.
The Cardinals will host the Falcons this Saturday from L&N Stadium at noon local time. Bowling Green holds a 2-1 record after the Falcons were able to beat Liberty and Lafayette, but they fell to the Cincinnati Bearcats 34-20 in Week 2. Now, the Cardinals will have their final "cupcake" matchup before they start their ACC games for the 2025 season, making this a crucial game for Jeff Brohm to address any concerns he still has.
Let's take a deep dive into FanDuel's early odds for this Week 4 matchup and make an early prediction.
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Louisville vs. Bowling Green Current Odds
Louisville opens up as a 26.5-point favorite as of Monday, September 15, at 6 a.m. EST. The Cardinals are double-digit favorites for their third straight game, and are favored by 20 points or more for their second game this season, according to FanDuel. The over-under for this Week 3 showdown is 51.5, and ESPN's Football Power Index is giving Brohm and his Cardinals a dominant 87.9 percent chance of winning this matchup.
Louisville vs. Bowling Green Prediction
Brohm is an excellent coach coming off a bye, as he holds a 10-4 record, and while the Falcons did just upset Liberty this past weekend, this should be another dominant win for Louisville. The Cardinals are much more physical and faster in every position, and with it being at home, Louisville fans don't have to worry about being on the national media upset watch for the second straight game.
The Cards have gone 0-2 against the spread this season so far, while Bowling Green is 1-0 against the spread on the road. Louisville will have a lot of points to cover on Saturday, but there should be no reason they can't get it done.
Louisville fans can expect a dominant performance from All-ACC running back Isaac Brown for the third straight game. And keep an eye out for tight end Jaleel Skinner in this game, and this is an opportunity for him to have his first breakout game of the 2025 season. The Cardinals get the job done again, dominate the Falcons, and turn their focus to Pitt and their ACC race.
Prediction: Louisville wins 45-14
Related: 3 biggest questions Louisville football must answer during their bye week
For all the latest on Louisville football's 2025 season, stay tuned.