Louisville football is coming off its first bye week of the 2025 season, and it will look to start 3-0 for yet another season. The Cardinals have earned two double-digit point wins in 2025 so far, and with Bowling Green coming into L&N Field, they have a good chance for a third.
Jeff Brohm and his Cardinals will kick off from L&N Stadium at noon local time against the Bowling Green Falcons. But before the game, here is a quick breakdown of the final odds of the game and a few predictions from the Big Red Louie.
Betting odds for Louisville vs. Bowling Green
Odds courtesy of FanDuel, and as of 6am ET on Friday, September 5th.
Spread: Louisville -26.5
Over/Under: 51.5
Moneyline: Louisville -4500
Final Staff Predictions:
William Begley
Louisville gets back on track and works to re-establish the offensive norm this week. Extra emphasis will be put on the pass game and working through the shortcomings seen in the second week win against JMU. Defense continues to shine and has another strong outing by dominating the line of scrimmage. Louisville enters Week 5 and the start of ACC play with confidence after a dominant win.
Prediction: Louisville 38 Bowling Green 10
Nick Zelano
Louisville’s offense will look a lot better, but Bowling Green will hang around enough to cover. Jeff Brohm took the bye week to work on establishing the run game, and the offense will be more consistent against a lesser opponent like Bowling Green. While there still may be some questions on the defense, the Cardinals shouldn't have to worry in this game as they should win by double-digits.
Prediction: Louisville 37 Bowling Green 17
Luke Santangelo
With the Cardinals eyeing an ACC push and their ACC games starting next week, Louisville fans should expect the best game of the season so far this afternoon. The ACC is wide open right now, with Miami as the favorite, but the Cardinals have a path to win their first ACC Title. So, with an opponent like Bowling Green coming to Louisville in Week 4 after a bye week, expect Miller Moss and Isaac Brown to run the show and dominate for the Cardinals.
Defensively, TJ Capers is a player fans should watch, as he will replace Stanquan Clark. The Cardinals' defense has looked sharp through two games, but now with Clark out, the fans are worried moving forward. That said, they won't be worried this week, and the Cardinals will win big. They won't cover, but they will look the part.