The wait is over. Louisville football is officially back as the Cardinals and the Eastern Kentucky Colonels are set to kick off at 3 p.m. local time from L&N Stadium. The Cardinals enter the third season under head coach Jeff Brohm and will look to carry the momentum from last season, as they won their final three games, including a tight Sun Bowl victory over Washington.
Louisville has emerged as a legitimate College Football Playoff contender in 2025 with their highly explosive offense, as the Cardinals' offense will be led by preseason All-American Isaac Brown and USC transfer quarterback Miller Moss. Louisville fans cannot wait to watch this team in action, and the good news is that they only have to wait a few more hours.
Related: 3 Louisville players poised for breakout performances Week 1 vs Eastern Kentucky
Odds provided by FanDuel:
Line: Louisville -38.5
Money Line: N/A
Over/Under: 56.5
Prediction
The Louisville Cardinals are going to open the season off hot just like they did last year to Austin Peay. This Cardinals team has an explosive offense, and they want to put on a show Week 1 for the fans. Expect running back duo Isaac Brown and Duke Watson to dominate the Colonels and each to run over 80 yards, and Miller Moss to have an eye-opening debut.
The Cardinals will dominate the trenches from start to finish and be the clear better team. Usually, in these FBS vs FCS games, the trenches are where fans will see the biggest gap of skill difference, and today will be no exception. The Cards' defensive line is going to be all over the Colonels' backfield and smother EKU's inexperienced offense. Louisville will cover the 38.5 as history suggests they will, and they will enter Week 2 1-0.
Prediction: 56-7
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