Jeff Brohm will look to secure Louisville football's third straight nine-win season and second 10-win season in three years. Brohm has emerged as one of the best coaches in college football since his arrival at his alma mater, and he will now look to take the Cardinals back to the ACC Championship game, but this time get over the hump and make history by winning the program's first-ever ACC Title.
Eastern Kentucky will travel to Louisville this Saturday to take on the Cardinals for an in-state battle in Week 1. Brohm and the Cardinals have high expectations entering the 2025 season, and it all starts this Saturday against the Cololnels from L&N Stadium. The Cardinals fans cannot wait for the season to start, and we have everything you need to know to be ready for this Week 1 battle in Louisville.
How to watch Louisville vs. EKU in Week 1
- Date: Saturday, August 30
- Time: 3:00 p.m. ET
- Venue: L&N Stadium
- How to Watch (TV): ACC Network
- Streaming: fubo TV
- Louisville record: 0-0
- Eastern Kentucky record: 0-0
Louisville vs. Eastern Kentucky odds, spread and total
Odds provided by FanDuel Sportsbook
Moneyline
- Louisville -N/A
- EKU N/A
Spread
- Louisville -38.5 (-110)
- EKU +38.5(-110)
Total
- 56.5 (over -110/under -110)
Louisville injury report
- No injuries reported
Eastern Kentucky injury report
- No injuries reported
ACCN announcers for Louisville vs. Eastern Kentucky
The ACC Network crew that will call the Week 1 showdown in Louisville will be Jorge Sedano on play-by-play and Rodney McLeod as the analyst. Victoria Arlen will join this duo down on the sidelines.
Weather forecast in Louisville
The skies are likely to be clear in Louisville on Saturday, with a high of 81 degrees and humidity around 50 percent. The weather will be perfect for September football, with a 3 p.m. kickoff time, and both teams, being from Kentucky, should be adjusted and ready to play on the Cardinals' turf.
Louisville and Eastern Kentucky series history
Louisville all-time record vs. EKU: 20-7-1
Last meeting, 2021 at home: 30-3 Louisville W
Related: Louisville football vs. Eastern Kentucky early odds and a prediction
For all the latest on Louisville football's 2025 season, stay tuned.