Louisville football is kicking off with the Miami Hurricanes this evening at 7 p.m. local time from Hard Rock Stadium. The Cardinals and Hurricanes had one of the best games of the college football season last year when Cam Ward and Tyler Shough dualed it out for four quarters, with the Hurricanes coming out on top 52-45.
Now, Louisville has its back against the wall, while Miami is on top of college football. The Cardinals are coming off a crushing overtime loss to Virginia a couple of weeks ago and then had a much-needed bye week to regroup and prepare for this blockbuster showdown. As for the Hurricanes, they are also coming off a bye week, having defeated Florida State 28-22 the week prior.
Louisville must win this game if it wants to keep its ACC Title chances alive, but on the road against the No. 2 team in the nation is no easy task. As for the Hurricanes, they are eyeing history and are trying to make their first appearance in the College Football Playoffs, and a win over Louisville is a massive step in the right direction. So, now that the stakes are set, let's break down the final odds of the game and make some predictions.
Betting odds for Louisville vs. Miami
Odds courtesy of FanDuel, and as of 6am ET on Friday, October 16th.
Spread: Miami -13.5
Over/Under: 50.5
Moneyline: Miami -590 Louisville +430
Big Red Louie Predictions
Louisville's season is on the line, and Jeff Brohm is usually good at getting his team ready for big-time games. The Cardinals have achieved historic wins since Brohm arrived at Louisville, highlighted by a massive win over Notre Dame in 2023 and the program's first victory over Clemson in 2024.
Miami has a reputation for slipping up and losing a game they should have won, and many had circled this game from the offseason. The Cardinals will be without key players in Stanquan Clark and Duke Watson, but many Louisville fans remain hopeful.
Brohm has an 11-4 record off a bye week in his last 15 games coming off a bye, but this Miami team is going to be one of the best teams he has ever faced. The Hurricanes' defense is legit, and Heisman favorite Carson Beck is leading this offense. The Cardinals are likely to come out with a chip on their shoulder after their loss to Virginia and will be fired up.
Picks:
Luke Santangelo: Miami 34, Louisville 20
Nick Zelano: Miami 31, Louisville 14
Caleb Meadows: Louisville 35, Miami 31
William Begley: Louisville 27, Miami 24
For all the latest on Louisville football's 2025 season and recruiting, stay tuned.