Louisville vs Virginia final odds and predictions

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Louisville football fans, the day is here for the Cardinals and the Cavaliers to matchup and play in their crucial ACC showdown at L&N Stadium. This matchup is one of two massive ACC clashes this weekend as the Florida State Seminoles will also face the Miami Hurricanes.

Louisville will look to gain respect from the league and the nation as it tries to pull off the upset over Virginia, which is ranked No. 24 in the country following its win over the Seminoles. The Cardinals are currently 4-0 after their historic comeback win over Pitt last week and are now 1-0 in conference standings.

These two teams are trying to solidify themselves as legitimate ACC contenders, and with a win today, the winner will do just that. Cardinals fans understand the magnitude of this game and expect to create an electric atmosphere, playing a crucial role in the outcome. So, all that said, let's take a look at the final odds and some predictions for this game.

Betting odds for Louisville vs. Virginia

Odds courtesy of FanDuel, and as of 6am ET on Friday, September 5th.

Spread: Louisville -6.5

Over/Under: 59.5

Moneyline: Louisville -235

Final Staff Predictions:

This is going to be a dogfight-type game. The game is going to be won in the trenches, and the defensive line will most likely win that battle for both teams. Louisville's offensive line will be the story of the day, and whether they can generate some gaps for Isaac Brown and Duke Watson.

This team must come out hot and play competitive football, just as they did in the second half against Pitt. This Cavaliers team can score, and they can do so quickly. The Cardinals' defense was dominant and a key reason why Louisville won last week, and they must dominate the trenches again, force pressure on Chandler Morris, and make plays happen.

This is the game where Brown breaks through and has a statement game. He is going to rush over 100 yards and will lead the Cardinals not just to a key ACC win but also to a skyrocketing position in the AP Polls before their massive showdown with Miami.

Prediction: Louisville 34 Virginia 30

Related: Louisville's Isaac Brown poised to make a massive statement against Virginia

Louisville and Virginia will kick off Saturday, October 4, from L&N Stadium at 3:30 p.m. local time.

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