Louisville football sits 6-1 on the 2025 season and 3-1 in their ACC games. The Cardinals' ACC odds continue to rise, and fans are increasingly confident this team can make a run and return to Charlotte.
The Cardinals are coming off an ugly win, but a win. Louisville defeated Boston College this past Saturday in a 38-24 victory at L&N Stadium. It was not pretty by any means, but the Cardinals fans saw Isaac Brown dominate and put on a show. Brown finished with 14 carries for 205 yards and one rushing touchdown.
However, the Cards turned the ball over three times, and the defense showed some concerns on the run and short passes. Now, Louisville will have to travel to Lane Stadium and take on the Virginia Tech Hokies in a crucial road game.
So, with Louisville fans hoping the Cardinals can make a run and have a shot at the ACC Title, here are the early odds for their showdown with Virginia Tech and an early prediction.
Louisville vs. Virginia Tech odds
Louisville will look to win its third straight game, but it won't be easy. Lane Stadium is known to pull off an upset no matter the Hokies' record, and this Saturday will be another big-time road test for Jeff Brohm's Cardinals. Louisville football opens up as 10.5-point favorites, and the over-under line is set to -53.5, according to FanDuel. ESPN Analytics gives the Cardinals a 73.6 chance of winning this game.
Louisville vs. Virginia Tech Prediction
The Cardinals avoided their letdown game last week, but will they do it again this week? The Cardinals had a massive road win over Miami two weeks ago, and history tells Louisville fans the road game following a big win is a recipe for disaster. The last two seasons, Louisville beat Notre Dame and Clemson, then went on the road the following week and lost to Pitt and Stanford.
The Cardinals got the win over Boston College, but now have that first road game after their big win. This Virginia Tech team is 3-5 on the year and is coming off an impressive win over Cal. Louisville must play a cleaner game this weekend if it wants to leave Blacksburg with a win, and a key way to do that is to take care of the ball.
The Cardinals can't have three turnovers on the road in that type of environment. This team has to come out swinging and ready to play, and can't play like it did against Pitt in the first quarter. Expect Brown to dominate once again as this Hokies run defense is in the bottom five in the conference. Virginia Tech gives up over 135 rushing yards a game, which is a recipe for success for Louisville. Brown will have to take care of the ball and stop these fumbles, but expect the All-American to lead Louisville to another key victory.
It will be closer than Louisville fans would like, but they will leave with a win and still in the hunt for the ACC Title.
Prediction: Louisville 31 Virginia Tech 24