Louisville has a massive Week 1 showdown with the Ole Miss Rebels. The Rebels are coming off an impressive Final Four run in the College Football Playoffs, and will hope to have their star quarterback, Trinidad Chambliss, back for next season. These two programs have only met once in their history, back in 2021 in Week 1, when Ole Miss defeated Louisville.
The Cardinals will look to rewrite the script as this will likely be a top-25 showdown. If Chambliss returns and is eligible, this Ole Miss team is dangerous and ranked as high as No. 5 in FOX's way-too-early rankings. Louisville will likely keep this game close and put on a good performance in the SEC/ACC showdown, but with the Rebels' experience and star quarterback, Louisville will fall in the opener in a one-score game.
Louisville starts 0-1 in 2026.