5. Virginia at Louisville (October 4th)
The Virginia Cavaliers have been one of the early bright spots of the ACC this season, starting the season with a 3-1 record. The Cavaliers have provided a high-flying aerial attack, led by quarterback Chandler Morris, who currently has 1,050 passing yards and eight passing touchdowns through the first four games. Virginia fell early in a close battle to the North Carolina State Wolfpack on the road, 35-31. However, the Cavaliers have had strong showings in their other games and will prove to be a formidable opponent for the Cardinals in the second week of ACC play.
Louisville will be coming home after a hard-fought matchup against the Pittsburgh Panthers, hoping to stay undefeated against the Cavaliers. This matchup will be a test of willpower for the Cardinals, who will undoubtedly be the favorites entering the matchup. The Cardinals will need to keep their focus and avoid looking ahead to the matchup with the Miami Hurricanes, which will occur the following week after the bye. Louisville should prevail, but keep an eye on this game as a potential letdown game for the Cardinals.
Related: Louisville football's 2025 ACC game-by-game predictions: Can Cardinals win the ACC?