4. Louisville at SMU (November 22nd)
The Louisville Cardinals will look to avenge their 7-point loss from last season against the SMU Mustangs as the last ACC matchup of the season. SMU has underperformed so far this season compared to its preseason expectations, losing early games to two Big 12 opponents, the Baylor Bears and the TCU Horned Frogs. However, SMU will still look to be a contender in the ACC as they open ACC play against the Syracuse Orange this week.
This matchup for the Cardinals will be Louisville's last chance to bolster its ACC resume and will likely have significant implications for the ACC title game. Traveling on the road to play at SMU will add an extra level of difficulty to the matchup for the Cardinals. This game will be the perfect final test for the Cardinals and will likely determine their fate in the ACC title race for the 2025 season.