Louisville football's 2025 ACC game-by-game predictions: Can Cardinals win the ACC?

With the Cardinals' ACC schedule kicking off this week against Pitt in Week 5, here are our final game-by-game predictions for Louisville football in the 2025 season.
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Week 5: vs Virginia (Oct. 4th)

The Virginia Cavaliers are 3-1 as of today, but they have to play Florida State next week and then travel to L&N Stadium the week after. The Cardinals will capitalize on a weaker team after they most likely lose to the Seminoles the week before.

UVA lost to North Carolina State earlier in the year, and coming off a physical battle with Florida State, the Cardinals should hold their ground and win this game pretty handily.

Prediction: Louisville 38 UVA 24

Related: ACC Title race explodes; Miami, Georgia Tech, Louisville rise as Clemson collapses

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