Louisville football 2025 game-by-game predictions

With spring practice under way, and Louisville football officially knows who they play this season, and when, let's take a deep dive and predict each game for this upcoming 2025 season.
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This game will be a great week-two test for Jeff Brohm and his Louisville Cardinals. The Cardinals will go head-to-head with James Madison University at home again, and it will be a great battle.

JMU is coming off an impressive 9-4 season, including a 70-50 victory over a fellow ACC team, North Carolina. Cardinals are much better than the Tar Heels and the skill position in this game with the Dukes will show.

The Dukes gave up 191.5 rushing yards per game last season, and that isn't a great recipe for this dominant rushing offense. Expect this offensive line and Isaac Brown to have a field day this game and take over.

While James Madison is an upgrade from week one's opponent Eastern Kentucky, the Cardinals will secure their second win of the season and start 2-0.