The Cardinals hit the road this Saturday as Jeff Brohm and this explosive offense take on Georgia Tech in a Week 10 matchup. Louisville enters this game on a three-game win streak after the Cardinals dominated Stanford last week, 52-24.
Louisville football vs. Georgia Tech: how to watch, odds, injuries, more for Week 10 matchup
The Cardinals enter this game in third place in the ACC standings with a 5-3 record in 2026, including a 4-2 record in conference play. UofL will try to improve to 2-1 on the road as they face the 2-6 Yellow Jackets in Atlanta.
Georgia Tech enters this matchup last in the ACC, with a 1-4 conference record and a recent three-game losing streak, including a 23-point loss to Pitt last week. With the stage set, let’s break down the final odds and make a final prediction.
Louisville vs. Georgia Tech odds
Brohm and Louisville are a two-touchdown favorite on the road, as Louisville enters Saturday -14.5 against Georgia Tech. The Cards have won the last two matchups against Georgia Tech, and with Louisville and Georgia Tech trending in opposite directions, Vegas oddsmakers are all in on the Cards.
Odds courtesy of FanDuel.
Spread: Louisville -14.5
Over/Under: 62.5
Moneyline: Louisville -630/Georgia Tech +460
Big Red Louie Predictions
In this matchup, all eyes should be on the Cardinals' rushing attack and Georgia Tech’s rushing defense. Louisville has the ninth-best rushing attack in college football, averaging 225.1 rushing yards per game. This rushing attack is led by preseason All-American Isaac Brown, who is averaging 88 yards per game and has rushed for 125 yards or more in three of the last four games, including last week's win, when he logged 139 yards on just nine carries.
Georgia Tech has allowed 34 points or more in its three-game losing streak, and the opposing team is averaging 39 points per game during this stretch. That is very eye-opening for this Cardinals offense, as Lincoln Kienholz and this unit rank No. 6 in the nation, averaging 40 points per game, and the star QB ranks No. 18 in the nation with 2,094 passing yards.
This should be a dominant offensive game for Louisville, and we see another double-digit win for the Cardinals, with Brohm and this squad to cover.
Prediction: Louisville 42 Georgia Tech 24
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