Louisville football is looking to build off its biggest win of the season and improve to 3-1. The Cardinals are coming off an impressive 41-31 win over SMU and have soared up the AP rankings to No. 16 in the nation entering week 4.
Wake Forest gets concerning injury news ahead of Louisville football showdown
The Cardinals are looking to build on their win over SMU and start their CFP run in Week 4. Louisville is emerging as a legit CFP contender and a major threat in the ACC, and Wake Forest is no cupcake opponent.
The Cardinals turn their attention to another ACC opponent as they face a 2-1 Wake Forest team. The Demon Deacons enter this game after battling Miami, but their comeback ultimately fell short, and they lost to the Hurricanes 33-20.
If Louisville wants to be a true CFP contender, they must take care of business this week, defeat the Demon Deacons, and improve to 3-1. So, with the Cardinals trying to climb the national rankings and emerge as a top team, let's break down how to watch, odds, injuries, and more.
How to watch No. 16 Louisville vs. Wake Forest in Week 4
- Date: Saturday, September 26th
- Time: 12:00 pm E.T.
- Venue: L&N Stadium
- How to Watch (TV): ESPN
- Streaming: fubo TV
- Louisville record: 2-1
- Wake Forest record: 2-1
What are the betting odds for Louisville vs. Wake Forest?
Odds courtesy of FanDuel.
Spread: Louisville -12.5
Over/Under: 58.5
Moneyline: Louisville -520/Wake Forest +385
Game odds refresh periodically and are subject to change.
Injury report for Louisville and Wake Forest
Louisville:
- TE Travis Egan: Out
- P Jacob Baker: Out
- OL Max Merz: Out
- OT: Bryten Close: Out
- OL Sam Secrest: Out
- WR Payton Cook: Out
- DL Sam Dawson: Out
- DB Antonio Watts: Doubtful
- DB Tayon Holloway: Questionable
Wake Forest:
- WR Ny Carr: Out
- QB Gio Lopez: Questionable
Louisville vs. Wake Forest history
The Cardinals and Demon Deacons have played 10 times, with Louisville leading the record at 7-3 against Wake Forest. The last time they played was in 2022, when Louisville won 48-21. In the past five games, Louisville is 3-2, as Wake Forest defeated Louisville in 2021 and 2018, and the Cards defeated the Demon Deacons in 2019 and 2020.
The Cardinals are 4-1 at home against Wake Forest, including wins in their last two home games, 48-21 and 45-21.
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