Louisville football is coming off one of its biggest wins in program history after the Cardinals completely stunned the No. 2 team in the country and the ACC frontrunner in the Miami Hurricanes. Louisville played its best game in the biggest opportunity and showed its full potential in the 24-21 win.
Now, the Cardinals are ranked No. 19 in the nation and are right back in the ACC race. The Cards are 5-1 on the season and 3-1 in the ACC. Louisville has a track record of winning big games under head coach Jeff Brohm, as the Cardinals defeated Notre Dame and Clemson in his first two seasons, but they also have a record of a letdown game after their big win.
Brohm and his Cardinals will look to change that narrative this weekend against Boston College. The Eagles are 1-6 in 2025 and have lost six straight games, including this past weekend to UConn 38-23. Louisville will return to L&N Stadium and will host Boston College for a 7:30 p.m. local kickoff.
So, with all the eyes on Louisville now, here are the early odds for their showdown with the Eagles and an early prediction.
Related: 5 immediate observations from Louisville’s massive upset over the Miami Hurricanes
Louisville vs Boston College odds
Louisville will look to send a message to the rest of the ACC this weekend as the Cardinals are due for a dominant performance. ESPN Analytics gives the Cardinals a 93.1 percent chance of winning this weekend, and FanDuel opens the spread in favor of Louisville. The Cardinals are dominant favorites as they are 23.5-point favorites with the over-under line set at 55.5.
Louisville vs. Boston College Prediction
Louisville is coming off its biggest game of the season and its most complete game of the season. The Cardinals were led by their stars on both sides of the ball, while the offensive line and Miller Moss stepped up and proved they are capable of playing elite football. There is going to be tons of emotion in L&N Stadium after a win like that, but this is the year Brohm changes the narrative and wins the game after a big game.
Louisville is going to dominate the line of scrimmage thks weekend, and Isaac Brown and Chris Bell are going to be a dynamic duo that the Eagles simply can't stop. This duo is poised for another massive game, while this defense is going to shutdown this underwhelming Eagles offense.
Louisville fans can expect maybe a close first quarter, but the Cardinals will run away with it in the second and third. Louisville is going to move on to 6-1 on the season and 4-1 in the ACC, and remain in the ACC race.
Prediction: Louisville 41 Boston College 17
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