Louisville football returns to action since its historic win over the Miami Hurricanes. The Cards return to L&N Stadium this evening at 7:30 p.m. local time against the 1-6 Boston College Eagles. The Cardinals are in the AP Polls for the first time all season after their massive win over Miami and will look to stay in the mix for the ACC Title and avoid a letdown game.
The Cardinals come into week 9 ranked No. 19 in the nation, and very much so alive for the ACC Title. The Cards have had a history of being upset the weekend following a big-time win, as Louisville lost at Pitt after a massive win over Notre Dame in 2023 and lost at Stanford last year after their win over Clemson.
Jeff Brohm has made it clear that they plan to rewrite history this weekend and avoid an upset and a letdown. So, with ACC Huddle in attendance and all eyes on the Cardinals after their big win, let's break down the final odds of the game and make some predictions.
Related: Jeff Brohm aims to rewrite history this weekend after massive win over Miami
Betting odds for Louisville vs. Boston College
Odds courtesy of FanDuel, and as of 7am ET on Friday, October 25th.
Spread: Louisville -25.5
Over/Under: 54.5
Moneyline: Louisville -4000
Predictions from The Big Red Louie team
Louisville football just shocked the nation last weekend with a massive win over Miami, and the fans are buzzing with excitement. The Cards' ACC Title odds soared through the roof as they jumped from +3000 to +550, making it clear they are right in the mix.
So, while Brohm has had letdown games in the past, something feels different this time around. This team just played its most complete game on the road and found the recipe for success. They have to win through their stars and get the ball out of Miller Moss's hands quickly. This Boston College defense is one of the worst in the league, and should give Louisville's offense almost no concerns.
Louisville should dominate this game from start to finish, and with the past two seasons of letdown games after big wins, expect Brohm to have this team ready to go. The Cardinals are going to win, and they are going to win big, improving to 6-1 on the year and 3-1 in ACC play.
Picks:
Luke Santangelo: Louisville 41 Boston College 13
For all the latest on Louisville football's 2025 season and recruiting, stay tuned.
