Louisville football is on a short week after the Cardinals' second straight loss, as Jeff Brohm and UofL face Florida State this Friday night. The Cards are desperate for a win; after starting 2-1 and looking like Miami’s biggest threat in the ACC, Louisville dropped two straight games, one against Wake Forest and last week against North Carolina State.
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While the Cardinals' ACC Title dreams aren’t officially dead, they are certainly on life support, and Friday night's showdown with the Seminoles has become a must-win if Louisville wants to go on any sort of run in 2026. Louisville enters Friday's matchup at 2-3, with wins over Villanova and SMU, while Florida State enters at 3-2, with losses to SMU and Alabama.
Friday should be a good matchup, especially since Louisville has lost all its games by three points. With Louisville in dire need of a win and FSU trying to emerge as an ACC contender, let’s break down how fans can watch and the key injuries.
How to watch Louisville vs. Florida State in Week 6
- Date: Friday, October 9th
- Time: 7:00 pm E.T.
- Venue: L&N Stadium
- How to Watch (TV): ESPN
- Streaming: fubo TV
- Louisville record: 2-3
- Florida State record: 3-2
What are the betting odds for Louisville vs. Florida State?
Odds courtesy of FanDuel.
Spread: Louisville -3.5
Over/Under: 59.5
Moneyline: Louisville -188/Florida State +155
Game odds refresh periodically and are subject to change.
Injury report for Louisville and NC State
Louisville:
- TE Travis Egan: Out
- P Jacob Baker: Out
- OT: Bryten Close: Out
- OL Sam Secrest: Out
- DL Sam Dawson: Out
- DB Antonio Watts: Out
- TE Hamilton Atkins: Out
- WR Montavin Quisenberry: Out
- DB TJ Banks: Questionable
- RB Keyjuan Brown: Questionable
- OL Cason Henry: Questionable
- DL Daylen Russell: Questionable
- QB Lincoln Kienholz: Probable
Florida State:
- RB Samuel Singelton Jr,: Out
- WR Devin Carter: Out
- DB Karson Hobbs: Out
- DB Jamari Howard: Out
- LB Blake Nichelsen: Out
- DB Zae Thomas: Out
- DB Jordan Crutchfield: Out
- LB Izaia Williams: Out
- LB Daylen Greene: Out
- LB Noah LaVelle: Out
Louisville vs. Florida State history
The history isn’t on the Cardinals' side in this must-win Friday night showdown, as the Cardinals are just 6-19 against FSU. Louisville is 3-7 at home and 3-9 on the road against Florida State, including a two-game losing streak to the Seminoles when they lost in the 2023 ACC Championship Game, and in 2022 when they lost 35-31 at home.
Now, Louisville will look to snap that losing streak and earn their first win over FSU since 2021. Since the Cardinals joined the ACC, the teams are even in conference play, with both going 4-4 against each other. Louisville faces heavy pressure in this Friday night showdown: a win could put them on a run with their favorable schedule, but a loss would drop them to 2-4, and the nail might be in the coffin.
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