Louisville football got off to a dominant start for the 2025 season as the Cardinals thumped Eastern Kentucky 51-17 last Saturday. Jeff Brohm and his Cardinals will now shift their focus to Friday night, where Louisville has a sneaky, challenging opponent in James Madison.
The Dukes are also coming off a solid Week 1 performance as they defeated Weber State 45-10. James Madison is expected to be a great test for Louisville in Week 2 and to get them ready for their ACC play in Week 5 against Pitt. The Cardinals fans cannot wait to watch Louisville play under the lights on a Friday night and pack out L&N Stadium. That said, here is everything Louisville fans need to know to be ready for this Week 2 battle.
How to watch Louisville vs. JMU in Week 2
- Date: Friday, September 5
- Time: 7:00 p.m. EST
- Venue: L&N Stadium
- How to Watch (TV): ESPN2
- Streaming: fubo TV
- Louisville record: 1-0
- James Madison record: 1-0
Louisville vs. James Madison odds, spread and total
Odds provided by FanDuel Sportsbook
Moneyline
- Louisville: -600
- JMU: +430
Spread
- Louisville: -13.5 (-110)
- JMU: +13.5(-110)
Total
- 58.5 (over -110/under -110)
Louisville injury report
Nate Kurisky-Out
Trevonte Sylvester- Out
Rodney Johnson Jr. - Active
Weather forecast in Louisville
The morning is expected to be high of 72, with a 77 percent chance of rain. The Cardinals and Dukes can expect possibly rainy conditions for their night game, but once the sun sets and the lights come on, it will be a fall-like atmosphere, with a high of 52 degrees.
ESPN 2 announcers for Louisville vs. James Madison
ESPN 2 will have Anish Shroff on the play-by-play for Louisville vs James Madison and Andre Ware as their analyst, and Paul Carcaterra on the sideline.
Louisville and James Madison series history
Louisville all-time record vs. JMU: 1-0
Last meeting, 2022 at home: 34-10 Louisville W
Related: Rodney Johnson Jr.'s injury update is the exact boost Louisville desperately needed
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