Louisville vs Pittsburgh final odds and predictions

Andy Lyons/GettyImages

Louisville football will take on the Pittsburgh Panthers in a few hours, and the Cardinals fans are buzzing with excitement. As the game grows closer, the Cardinals fans are wondering if their star running backs Issac Brown and Duke Watson are going to play, and if Pitt's star running back Desmond Reid is going to play.

This showdown is a crucial game for the Cardinals' ACC Title odds, especially after Florida State fell last night. The ACC race is wide open for the second spot, and with Louisville's game against Pitt at noon local time, the Cards have an opportunity to put themselves on everyone's radar.

Betting odds for Louisville vs. Pittsburgh

Odds courtesy of FanDuel, and as of 6am ET on Friday, September 27th.

Spread: Louisville -3.5

Over/Under: 56.5

Moneyline: Louisville -172

Final Predictions:

Whether the Cardinals have their two running backs or just one, this team will beat Pitt for the first time on the road since joining the ACC. Louisville has too many playmakers and weapons on the outside, and this feels like a game where Miller Moss steps up and proves himself, given the uncertainty surrounding the running backs.

Last year, Louisville steamrolled Pitt 37-9, and while it won't be that big of a blowout this year, Louisville will get the job done and improve to 4-0. The Cardinals' defense is going to lead them to a victory today with Clev Lubin and TJ Quinn dominating that side of the ball. On offense, expect Caullin Lacy to have another massive big game, whether that is special teams, or as a wide receiver or running back. Louisville goes into Acrisure Stadium and will leave with a massive victory of 31-24, and takes a big jump in the AP Polls and ACC race.

Prediction: Louisville 31 Pitt 24

Related: 5 reasons why the Louisville Cardinals will dominate the Pitt Panthers this weekend

The Cardinals and Panthers will kick off at noon local time in a crucial ACC showdown.

Loading recommendations... Please wait while we load personalized content recommendations