Louisville football heads on the road this afternoon in a crucial game to keep their ACC Title chances alive. The Cards are fighting to secure one of the top two seeds in the conference, returning to Charlotte for the second time in three years and attempting to claim the ACC crown. The Cards look to make history this afternoon and earn their first road win at Lane Stadium, as Louisville is 0-3 in Blacksburg and is 3-6 overall against VT.
The Cards are 6-1 on the season and are 3-1 in the ACC. The Cards and the Hokies will kick off from Lane Stadium this afternoon at 3 p.m. local time. Louisville will be without Stanquan Clark for another week as he continues his recovery, and running back Duke Watson will also be out. The Hokies are 3-5 and are coming off a gritty win over Cal in overtime. Louisville is going to face a challenge on the road this week, and if they want to keep their ACC Title and CFP chances alive, they have to win this afternoon.
So, that said, let's dive into the final odds and some predictions.
Betting odds for Louisville vs. Virginia Tech
Odds courtesy of FanDuel, and as of 7am ET on Saturday, Nov. 1.
Spread: Louisville --10.5
Over/Under: 54.5
Moneyline: Louisville -390
Related: 3 bold predictions for Louisville football vs. Virginia Tech
Predictions from The Big Red Louie team
Louisville's offense must exploit this Hokies defense and rely on its stars, Isaac Brown and Chris Bell. Brown is coming off a dominant rushing game against Boston College, where he ran for over 200 yards, and with Keyjuan Brown stepping up behind him, this rushing game is starting to flourish at the right moment. The Hokies' defense struggles to stop the run, allowing 184 yards on the ground per game, and 189 yards through the air per game.
A key emphasis for this game in a challenging environment is to take control of the ball and minimize turnovers. The Cardinals must hold onto the ball, as fumbles are beginning to add up, and it isn't easy to win on the road while turning the ball over. If the Cardinals can take care of the ball and rely on their stars, as they have on offense, then they should be able to run away with this game in the fourth quarter.
The Cardinals' defense has been impressive all year, and this Hokies offense scored higher than 26 points for the first time just last weekend in an overtime thriller. Their offense is averaging 25.4 points per game, making it likely that VT will struggle to keep up with the Cardinals' explosive offense.
Picks:
Luke Santangelo: Louisville 31 Boston College 23
Nick Zelano: Louisville 28 Virginia Tech 21
William Begley: Louisville 31 Virginia Tech 17
For all the latest on Louisville football's 2025 season and recruiting, stay tuned.