Louisville football is looking to win its second straight game as the Cardinals face the 2-3 Syracuse Orange this weekend on the road in the JMA Wireless Dome. Jeff Brohm and the Cardinals have had a roller coaster season so far, with Louisville upsetting SMU and playing Ole Miss super close, but then dropping their next two conference games, putting them at 3-3 as they enter this Week 7 matchup.
3 bold predictions for Louisville vs. Syracuse in Week 7
The Cardinals are 0-2 on the road this season, including their loss to NC State a couple of weeks ago. Now, UofL will look to flip the script and secure their first road win of the season, as they are trending as a two-touchdown favorite against the Orange on Saturday night.
Saturday should be a game where this Cardinals squad gains more confidence and builds on that spark Louisville got back from their huge Florida State win last week. With the game quickly approaching and the Cardinals looking to secure their fourth win, let’s break down how fans can watch and the key injuries.
How to watch Louisville vs. Syracuse in Week 7
- Date: Saturday, October 17th
- Time: 7:30 pm E.T.
- Venue: JMA Wireless Dome
- How to Watch (TV): ACC Network
- Streaming: fubo TV
- Louisville record: 3-3
- Syracuse record: 2-3
What are the betting odds for Louisville vs. Syracuse?
Odds courtesy of FanDuel.
Spread: Louisville -15.5
Over/Under: 55.5
Moneyline: Louisville -675/Syracuse +490
Game odds refresh periodically and are subject to change.
Injury report for Louisville and Syracuse
Louisville:
- TE Travis Egan: Out
- P Jacob Baker: Out
- OT: Bryten Close: Out
- OL Sam Secrest: Out
- DL Sam Dawson: Out
- DB Antonio Watts: Out
- TE Hamilton Atkins: Out
- DB DJ Waller Jr.: Out
- OL Anwar O'neal: Out
- DL Micah Carter: Questionable
- RB Keyjuan Brown: Questionable
- OL James Glover-Tyson
- T: Dylan Mesman
Syracuse:
- WR Darrien Williams: Out
- QB Amari Odom: Out
- OL: Jackson Iak: Out
- OL D'Joni Scatliffe: Out
Busy quarterback injury report for Syracuse against Louisville. Amari Odom is out, Steve Angeli is questionable and last week's starter, Malachi Nelson, is also questionable. Louisville RB Keyjuan Brown is also questionable. pic.twitter.com/QUJ21wIbOK
— Pete Thamel (@PeteThamel) October 15, 2026
Louisville vs. Syracuse history
Louisville and Syracuse have met 21 times, with the Cardinals leading the Orange 13-8. When Louisville and Syracuse have shared a conference, they have met eight times, with UofL dominating 6-2.
However, the last two times these two teams met, Syracuse beat Louisville 31-7 in 2022 and 54-23 in 2018. When the Cardinals travel to Syracuse, the teams are even at 5-5, but in the last 10 matchups, Louisville has dominated,, winning seven, including three of the last four.
Now, UofL will look to win its first road game against Syracuse since 2016, when the Cardinals won 62-28.
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